Students will develop the ability to reason logically and
critically, acquire an appreciation of the contributions of
research in the pharmaceutical sciences to the underpinning
of advances in the health care of the community, and, where
appropriate, receive encouragement to pursue research interests.
They will also develop learning skills and motivation to provide
the basis for self-directed continuing education and acquire
knowledge, skills and attitudes appropriate for further education
in any pharmaceutical specialty. Students will demonstrate
competence in the application of medical knowledge and attitudes
of professionalism to the needs and expectations of company
laboratories, government, and school. There are three departments
in the graduate school: Department of Pharmaceutical Science,
Department of Clinical Pharmacy, and Department of Oriental
Pharmaceutical Science. Each department offers a Master's
course, Ph.D. course and Master-Ph.D. unified course.
The Department of Pharmaceutical Science in the Graduate School
offers academic/clinic courses that lead to application of
the knowledge and research ability in pharmaceutical sciences
as well as leadership in the community. We aim to provide
world-class education for the next generation of pharmacists
and pharmaceutical engineers in careers such as new drug development,
structure analysis, hygienic chemistry pharmaceutics, pharmacokinetics,
and herbology in order to contribute to a disease-free society.
Students will
1)study new drug developments including synthetic compounds,
natural products,
and oriental medical sources.
2)prepare to have the ability to reason logically and provide
the chance to develop creativity to can contribute to the
globalization of the world.
3)prepare to have the research ability for alternative medicines
with profound understanding of Western and Eastern medicines.
4)prepare to have teaching skills through hands-on experiences
in the laboratory and classes.
The Department of Clinical Pharmacy in the Graduate School
offers academic/clinic courses that lead to application of
the knowledge and research ability in pharmaceutical sciences
as well as leadership in the community. We aim to provide
world-class education to the next generation of pharmacists
and pharmaceutical engineers in careers such as clinical chemistry,
clinical pharmacy, hospital pharmacy, new drug development,
hygienic chemistry pharmaceutics, pharmacokinetics, and Herbology
in order to contribute to a disease-free society.
Students will
1)study the new drug development and estimation from a lot
of clinical data and information.
2)prepare to have the ability to reason logically and provide
the chance to develop creativity to contribute to the globalization
of the world.
3)prepare to have the research ability for alternative medicines
with profound understanding of Western and Eastern medicines.
4)prepare to have teaching skills through hands-on experiences
in the laboratory and classes.
To receive the Master of Science in Pharmaceutical Science,
a student must
1) complete 24 units for general professional courses
2) satisfy the English proficiency requirement, and
3) submit the acceptable thesis to be approved by a faculty
committee.
To receive the Philosophy Degree of Science
in Pharmaceutical Science, a student must
1) complete a minimum of 36 units for general professional
courses
2) satisfy the English proficiency requirement, and
3) submit the acceptable thesis to be approved by a faculty
committee.
(All courses to be offered are shared by MS courses and Ph.
D. courses)
Medicinal Plant and Experimental Pharmacal Botany, Pharmaceutical
Inorganic Chemistry and Laboratory, Pharmaceutical Biology,
Pharmaceutical English, Anatomic Physiology, Physical Pharmacy
and Laboratory, Pharmaceutical Organic Chemistry, and Laboratory,
Inorganic Pharmaceutical Manufacturing Chemistry, Pharmaceutical
Qualitative Analytical Chemistry, Pharmaceutical Quantitative
Analytical Chemistry, Instrumental Methods of Structural Analysis,
Computer for Pharmacy, Synthetic Organic Chemistry and Laboratory,
Biochemistry and Laboratory, Hygienic Chemistry and Laboratory,
Microbiology and Laboratory, Pathology, Endocrinology, Pharmacokinetics,
Genetic Engineering, Environment Hygienic Chemistry, Industrial
Pharmacy, Clinical Pharmacy, Nutritional Chemistry, Chemistry
of Chemotherapeutics, Anatomy and Physiology, Pharmaceutics
and Laboratory, Pharmacology and Laboratory, Pharmacopoeia
and Laboratory, Pharmaceutical Jurisprudence, New Drug Development,
Herbology, Toxicology
Se-Young
Choung, Ph.D.
[University of Tokyo, 1987, Professor, Hygienic Chemistry
and Toxicology, sychoung@khu.ac.kr]
Seong-Hyun Jung, Ph.D.
[State University of New York, 1987, Professor, Pharmacology,
suchung@khu.ac.kr]
Dong-Hyun Kim, Ph.D.
[Toyama Medical and Pharmacetutical University, Japan, 1987,
Professor, Microbiology, dhkim@khu.ac.kr]
Kyung-Tae Lee, Ph.D.
[Leuven University, Belgium, 1991, Professor, Biochemistry,ktlee@khu.ac.kr]
Seo-Young Jeong, Ph.D.
[University of Utah, 1984, Professor, Pharmacertics, syjeong@khu.ac.kr]
Jin-Hyun Jeong, Ph.D.
[Stanford University, 1993, Associate Professor, Organic Synthesis
and Medicinal Chemistry,
jeongjh@khu.ac.kr]
Young-Sup Lee, Ph.D.
[Korea Advanced Institute of Science and Technology, 1992,
Associate Professor, Chemistry and Medicinal Chemistry kyslee@khu.ac.kr]
Bioinorganic & Analytical Lab
One of the most important issues in bioinorganic chemistry
is the nature of enzyme catalysis. We have tried to mimic
the chemical environment of active enzymes in synthetically
prepared analogues and organometals such as organoplatinum
compounds. In addition, we focus on analytical chemistry involving
structural analysis and quantitative analysis.
Pharmaceutic & Drug Delivery
Laboratory
Pharmaceutics is the study of the relationships between drug
delivery, drug disposition and clinical response. The research
areas of pharmaceutics encompass molecular design and evaluation
of drug delivery systems, preformulation, physical pharmacy,
drug metabolism and transport processes, pharmacokinetics,
and pharmacogenomics. With the recent progress in biotechnology,
contemporary pharmaceutics places a strong emphasis on understanding
and exploiting the principles underlying the delivery of large
molecular bioactive entities such as genes or proteins.
Pharmacology and Clinical Pharmacy
Laboratory
Three research fellows (two majors in cell biology and one
in analytical chemistry), four graduate students (two for
the master's program and two doctoral candidates) and one
technician are now guided by Prof. Chung Sung Hyun. We are
mainly working on development of antidiabetic and antiobese
drugs from natural products. Recently we are also working
on mechanism studies of the anti-inflammatory activity of
Darae fruits. Working with a pharmaceutical company, the formulation
study is nearly completed. Toxicity and clinical study for
antidiabetic agent, developed from a Korean traditional oriental
prescription, will be conducted in 2004-2005.
Hygienic Chemistry Laboratory
The main research is the development of healthy functional
foods and new drugs from natural products which improve the
treatment of chronic diseases (obesity, hyperlipidemia, diabetic).
Additional research looks into diminished drug toxicity, disease
prevention, and treatment against environmental contamination
materials (drug, a heavy metal, agricultural medicine, environment
hormone) through research of toxic degree and mechanism of
agents which have serious side effects.
This lab covers subjects such as hygienic chemistry, environment
toxicology, toxic biochemistry, qualitative analytical chemistry,
development of healthy functional food .
Ongoing Projects
1. Study of mechanism of nephrotoxicity by heavy metal, drug(anticancer,
antibiotic, antifebrile) and development of nephotoxocity
lowering agent from natural product
2. The development of healthy functional food and new drug
which is effective for obesity, hyperlipidemia, and alcoholic
fatty liver
3. The development of healthy functional food and new drug
which is effective for diabetic
4. The development of healthy functional food and new drug
which is effective for beauty (whiting, anti-wrinkle, moisturizing)
5. The development of natural product which is prevent from
environment hormone (dioxin, bisphenol A etc)
Microbiology & Immunology Laboratory
Most herbal medicines, which have been used in China, Korea
and Japan, are orally administered to humans. Therefore, their
components are inevitably brought into contact with intestinal
microflora in the alimentary tract. The intestinal bacteria
transform these components before absorption from the gastrointestinal
tract. Therefore, intestinal bacteria related to the metabolism
of the components of herbal medicines should be an important
factor to understand herbal biological activities. Our lab
mainly studies the relationship between the metabolism of
natural products and their biological activities such as antiallergic,
antiviral, antihyperlipidemic activities.
Ongoing Projects
1. Development of hepatoprotective agents from beta-glucuronidase
inhibitors of natural products.
2. Developmment of antirotaviral probiotics
3. Purification of glycosaminoglycan-degrading enzymes from
Bacteroides HJ-15
Biochemisty Lab oratory
Prof. Lee Kyung Tae's speciality is signal transduction of
cell cycle/ apoptosis/differentiation mediating inflammation
and oxidation stress-mediated cell death and its chemoprevention
and/or chemotherapy. In addition, we are focused on ADME study
in animals as well as bioequivalence study in humans. Alumni
who studied in this lab are currently lecturing at universities
or working at the labs of well-known domestic pharmaceutical
companies. One post-doctorate researcher, 2 graduate students,
1 in combined doctorate and master's course and 11 in master's
course are putting their best efforts into making the lab
a world-class laboratory.
Ongoing Projects
1. Studies on the signal transduction of apoptosis and differentiation
by natural /synthetic compounds
2. Evaluation of in vitro and in vivo anti-inflammatory activities
and their mechanism of various natural/synthetic compounds
3. Screening and mechanism of cell-cycle inhibitors isolated
from natural compounds.
4. In vivo and in vitroanalytical condition, absorption and
metabolism of preclinical drugs.
5. Bioavailability and bioequivalence study of clinical use
drug
Organic & Medicinal Chemistry Laboratory
Medicinal chemistry is at the forefront of drug development,
blending synthetic chemistry, molecular modeling, computational
biology, structural genomics, and pharmacology to discover
and design new drugs, and investigate their interaction at
the molecular, cellular, and whole-animal level. This lab
is forging combinatorial chemistry and natural product synthesis.
by continuing the design and synthesis of lead compounds to
be expected or known compounds. Particularly, we focus on
indole library using solid phase reaction, carbohydrate library,
selenofalvonoid synthesis, and terpenoid synthesis to be expected
for the biological neuroeffective compounds. Also, we have
applied enzymatic reaction to offer chiral drug intermediate
by kinetic or dynamic resolution.
Ongoing Projects
1. Development of preclinical candidates for treatment of
stroke
2. Asymmetric syntheses and optical resolution technology
for biologically active compounds
3. Indole library for the treatment of stroke
